The University of Gothenburg tackles society’s challenges with diverse knowledge. 53 500 students and 6 500 employees make the university a large and inspiring place to work and study. Strong research and attractive study programs attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.
The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases and find new ways to diagnose and treat them.
The Institute is composed of the following four departments:
- The Department of Infectious Diseases
- The Department of Microbiology and Immunology
- The Department of Medical Biochemistry and Cell Biology
- The Department of Laboratory Medicine
At present, the institute has about 360 employees and approximately 450 million SEK in total assets
Subject area
Computational genomics of UV-induced DNA damage
Subject area description
We are interested in how mutations arise and distribute across genomes, in both protein-coding and non-coding DNA, and with a particular focus on ultraviolet (UV) light and skin cancers. For these studies we make use of publicly available as well as in-house generated genomic datasets, including genome-wide mapping of UV-induced DNA damage by high-throughput sequencing (CPD-seq). We now seek a skilled computational scientist to help address new challenges that will be tackled using this approach and related methods, in human cancer and beyond.
Job assignments
The project will involve bioinformatics analysis of large-scale genomic data generated in our lab, including integration with relevant public datasets. Although the emphasis will be on applied genomic science, the development of a new bioinformatics methodology may also be required to meet project goals. The work will be carried out in collaboration with experimental scientists. Relevant recent publications from our group include Elliott et al., Nature Rev. Cancer 2021; Van den Eynden et al., Nature Genetics 2019, Lindberg et al, PNAS 2019; Elliott et al., Plos Genetics 2018; Fredriksson et al., Plos Genetics 2017; Fredriksson et al., Nature Genetics 2014. See www.larssonlab.org for more information.
Assessment
Good programming skills and Linux/Unix experience is a requirement. Knowledge of Matlab or R is desired. Previous experience with the analysis of next-generation sequencing data is recommended. While not required, experience from relevant biological fields is desirable, and the applicant is expected to have published several articles in peer-reviewed journals. Excellent communicative skills are required, including fluency in oral and written English.
Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 – 4 of the Higher Education Ordinance.
Employment
The employment is full-time and temporary, two years, with placement at the Institute of Biomedicine. The first day of employment as agreed.